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Research
Projects

Project Title: Neurobiology and Genetics of Autism

COE Investigator: Robert D. Abbott

Collaborating Investigator: Geraldine Dawson (UW Psychology)

Funding Source: National Institute of Child Health and Human Development

Start/End Dates: 6/2002 - 6/2007

This project has five objectives: (1) to deepen our understanding of the neurobiological bases of autism by investigating the relationships among brain structure, brain chemistry, and function over time; (2) to determine whether the syndrome of autism is composed of meaningful and valid subtypes characterized by distinct etiologies, structural and metabolic brain abnormalities, neurocognitive profiles, developmental courses, and patterns of symptom expression; (3) to improve methods of early identification; (4) to identify early behavioral, neurocognitive, and biological predictors of outcome in autism, including early precursors of language and social development; and (5) to investigate the genetic basis of autism by developing quantitative autism phenotypic measures and by using genetic heterogeneity/ subtypes.

Selected related publications

Dawson, G., Munson, J., Estes, A., Osterling, J., McPartland, J., Toth, K., Carver, L., & Abbott, R. (2002). Neurocognitive function and joint attention ability in young children with autism spectrum disorder. Child Development, 73, 345- 358.

Dawson, G., Meltzoff, A., Osterling, J., & Rinaldi, J. (1998). Neuropsychological correlates of early symptoms in autism. Child Development, 69, 1276- 1285.

Unis, A., Munson, J., Rogers, S. J., Goldson, E., Osterling, J., Gabriels, R., Abbott, R. D., & Dawson, G. (in press). A randomized, double-blind, placebo controlled trial of porcine versus synthetic secretin for reducing symptoms of autism. Journal of the American Academy of Child and Adolescent Psychiatry.

Projects


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